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1s70

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{{STRUCTURE_1s70| PDB=1s70 | SCENE= }}
{{STRUCTURE_1s70| PDB=1s70 | SCENE= }}
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'''Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)'''
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===Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)===
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==Overview==
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The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. The human genome encodes a far greater number of Ser/Thr protein kinases than of phosphatases. Protein phosphatase 1 (PP1), in particular, is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits. The regulatory subunits are generally unrelated, but most possess the RVxF motif, a canonical PP1-binding sequence. Here we reveal the crystal structure at 2.7 A resolution of the complex between PP1 and a 34-kDa N-terminal domain of the myosin phosphatase targeting subunit MYPT1. MYPT1 is the protein that regulates PP1 function in smooth muscle relaxation. Structural elements amino- and carboxy-terminal to the RVxF motif of MYPT1 are positioned in a way that leads to a pronounced reshaping of the catalytic cleft of PP1, contributing to the increased myosin specificity of this complex. The structure has general implications for the control of PP1 activity by other regulatory subunits.
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(as it appears on PubMed at http://www.pubmed.gov), where 15164081 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15164081}}
==About this Structure==
==About this Structure==
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[[Category: Mypt1]]
[[Category: Mypt1]]
[[Category: Pp1]]
[[Category: Pp1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:22:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:33:29 2008''

Revision as of 02:33, 28 July 2008

Image:1s70.png

Template:STRUCTURE 1s70

Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)

Template:ABSTRACT PUBMED 15164081

About this Structure

1S70 is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of protein phosphatase 1 regulation., Terrak M, Kerff F, Langsetmo K, Tao T, Dominguez R, Nature. 2004 Jun 17;429(6993):780-4. Epub 2004 May 26. PMID:15164081

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