1s79

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{{STRUCTURE_1s79| PDB=1s79 | SCENE= }}
{{STRUCTURE_1s79| PDB=1s79 | SCENE= }}
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'''Solution structure of the central RRM of human La protein'''
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===Solution structure of the central RRM of human La protein===
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==Overview==
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The La protein is a conserved component of eukaryotic ribonucleoprotein complexes that binds the 3' poly(U)-rich elements of nascent RNA polymerase III (pol III) transcripts to assist folding and maturation. This specific recognition is mediated by the N-terminal domain (NTD) of La, which comprises a La motif and an RNA recognition motif (RRM). We have determined the solution structures of both domains and show that the La motif adopts an alpha/beta fold that comprises a winged-helix motif elaborated by the insertion of three helices. Chemical shift mapping experiments show that these insertions are involved in RNA interactions. They further delineate a distinct surface patch on each domain-containing both basic and aromatic residues-that interacts with RNA and accounts for the cooperative binding of short oligonucleotides exhibited by the La NTD.
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(as it appears on PubMed at http://www.pubmed.gov), where 15004549 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15004549}}
==About this Structure==
==About this Structure==
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1S79 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S79 OCA].
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1S79 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S79 OCA].
==Reference==
==Reference==
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[[Category: Alpha/beta]]
[[Category: Alpha/beta]]
[[Category: Rrm]]
[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:48:43 2008''

Revision as of 03:48, 28 July 2008

Image:1s79.png

Template:STRUCTURE 1s79

Solution structure of the central RRM of human La protein

Template:ABSTRACT PUBMED 15004549

About this Structure

1S79 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein., Alfano C, Sanfelice D, Babon J, Kelly G, Jacks A, Curry S, Conte MR, Nat Struct Mol Biol. 2004 Apr;11(4):323-9. Epub 2004 Mar 7. PMID:15004549

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