1s7a

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{{STRUCTURE_1s7a| PDB=1s7a | SCENE= }}
{{STRUCTURE_1s7a| PDB=1s7a | SCENE= }}
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'''NMR structure of the La motif of human La protein'''
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===NMR structure of the La motif of human La protein===
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==Overview==
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The La protein is a conserved component of eukaryotic ribonucleoprotein complexes that binds the 3' poly(U)-rich elements of nascent RNA polymerase III (pol III) transcripts to assist folding and maturation. This specific recognition is mediated by the N-terminal domain (NTD) of La, which comprises a La motif and an RNA recognition motif (RRM). We have determined the solution structures of both domains and show that the La motif adopts an alpha/beta fold that comprises a winged-helix motif elaborated by the insertion of three helices. Chemical shift mapping experiments show that these insertions are involved in RNA interactions. They further delineate a distinct surface patch on each domain-containing both basic and aromatic residues-that interacts with RNA and accounts for the cooperative binding of short oligonucleotides exhibited by the La NTD.
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{{ABSTRACT_PUBMED_15004549}}
==About this Structure==
==About this Structure==
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1S7A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7A OCA].
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1S7A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7A OCA].
==Reference==
==Reference==
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[[Category: La motif]]
[[Category: La motif]]
[[Category: Winged helix domain]]
[[Category: Winged helix domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:28:52 2008''

Revision as of 13:28, 28 July 2008

Image:1s7a.png

Template:STRUCTURE 1s7a

NMR structure of the La motif of human La protein

Template:ABSTRACT PUBMED 15004549

About this Structure

1S7A is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein., Alfano C, Sanfelice D, Babon J, Kelly G, Jacks A, Curry S, Conte MR, Nat Struct Mol Biol. 2004 Apr;11(4):323-9. Epub 2004 Mar 7. PMID:15004549

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