We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1s7t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s7t.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1s7t.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s7t| PDB=1s7t | SCENE= }}
{{STRUCTURE_1s7t| PDB=1s7t | SCENE= }}
-
'''Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants'''
+
===Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants===
-
==Overview==
+
<!--
-
Lymphocytic choriomeningitis virus infection of H-2(b) mice generates a strong CD8(+) CTL response mainly directed toward three immunodominant epitopes, one of which, gp33, is presented by both H-2D(b) and H-2K(b) MHC class I molecules. This CTL response acts as a selective agent for the emergence of viral escape variants. These variants generate altered peptide ligands (APLs) that, when presented by class I MHC molecules, antagonize CTL recognition and ultimately allow the virus to evade the cellular immune response. The emergence of APLs of the gp33 epitope is particularly advantageous for LCMV, as it allows viral escape in the context of both H-2D(b) and H-2K(b) MHC class I molecules. We have determined crystal structures of three different APLs of gp33 in complex with both H-2D(b) and H-2K(b). Comparison between these APL/MHC structures and those of the index gp33 peptide/MHC reveals the structural basis for three different strategies used by LCMV viral escape mutations: 1) conformational changes in peptide and MHC residues that are potential TCR contacts, 2) impairment of APL binding to the MHC peptide binding cleft, and 3) introduction of subtle changes at the TCR/pMHC interface, such as the removal of a single hydroxyl group.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15100292}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15100292 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15100292}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Lcmv]]
[[Category: Lcmv]]
[[Category: Mhc class i]]
[[Category: Mhc class i]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:24:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:07:04 2008''

Revision as of 12:07, 28 July 2008

Image:1s7t.png

Template:STRUCTURE 1s7t

Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants

Template:ABSTRACT PUBMED 15100292

About this Structure

1S7T is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition., Velloso LM, Michaelsson J, Ljunggren HG, Schneider G, Achour A, J Immunol. 2004 May 1;172(9):5504-11. PMID:15100292

Page seeded by OCA on Mon Jul 28 15:07:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s7t"
Personal tools