1s80

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{{STRUCTURE_1s80| PDB=1s80 | SCENE= }}
{{STRUCTURE_1s80| PDB=1s80 | SCENE= }}
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'''Structure of Serine Acetyltranferase from Haemophilis influenzae Rd'''
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===Structure of Serine Acetyltranferase from Haemophilis influenzae Rd===
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==Overview==
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The crystal structure of serine acetyltransferase (SAT) from Haemophilus influenzae Rd determined at 2.7 A resolution is presented. SAT is a member of a family of hexapeptide-containing transferases that contain six-residue tandem repeats (LIV)-G-X(4) that have been shown to form left-handed parallel beta-helices. In the current structure, each protomer is comprised of two domains: an N-terminal alpha-helical domain and a C-terminal left-handed parallel beta-helix domain. Although other members of this protein family are known to form trimeric structures, SAT forms a dimer of trimers in which the trimer interface is mediated through interactions between both the beta-helix domains and N-terminal domains; these trimers dimerize through contacts in the N-terminal domain. All dimer-of-trimer interactions are mediated through amino acids within an N-terminal extension common only to a subset of SATs, suggesting that members of this subfamily may also adopt hexameric structures. Putative active sites are formed by crevices between adjacent protomers in a trimer. Thus, six independent active sites exist in the hexameric enzyme complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 15333931 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15333931}}
==About this Structure==
==About this Structure==
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[[Category: Serine acetyltransferase]]
[[Category: Serine acetyltransferase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:24:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:17:48 2008''

Revision as of 00:17, 28 July 2008

Image:1s80.png

Template:STRUCTURE 1s80

Structure of Serine Acetyltranferase from Haemophilis influenzae Rd

Template:ABSTRACT PUBMED 15333931

About this Structure

1S80 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of serine acetyltransferase from Haemophilus influenzae Rd., Gorman J, Shapiro L, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1600-5. Epub 2004, Aug 26. PMID:15333931

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