1v9u
From Proteopedia
(New page: 200px<br /> <applet load="1v9u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v9u, resolution 3.6Å" /> '''Human Rhinovirus 2 b...) |
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| - | [[Image:1v9u.gif|left|200px]]<br /> | + | [[Image:1v9u.gif|left|200px]]<br /><applet load="1v9u" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1v9u" size=" | + | |
caption="1v9u, resolution 3.6Å" /> | caption="1v9u, resolution 3.6Å" /> | ||
'''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein'''<br /> | '''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Although many viral receptors have been identified, the ways in which they | + | Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium-chelating residues and, in particular, by an exposed tryptophan that is highly conserved. The attachment site on the virus involves only residues from VP1, particularly a lysine strictly conserved in all minor group HRVs. The disposition of the attached ligand-binding repeats around the five-fold axis, together with the proximity of the N- and C-terminal ends of adjacent modules, suggests that more than one repeat in a single receptor molecule might attach simultaneously. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1V9U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2] with CA and DAO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1V9U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DAO:'>DAO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V9U OCA]. |
==Reference== | ==Reference== | ||
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[[Category: vldl-receptor]] | [[Category: vldl-receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:33:13 2008'' |
Revision as of 13:33, 21 February 2008
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Human Rhinovirus 2 bound to a fragment of its cellular receptor protein
Contents |
Overview
Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium-chelating residues and, in particular, by an exposed tryptophan that is highly conserved. The attachment site on the virus involves only residues from VP1, particularly a lysine strictly conserved in all minor group HRVs. The disposition of the attached ligand-binding repeats around the five-fold axis, together with the proximity of the N- and C-terminal ends of adjacent modules, suggests that more than one repeat in a single receptor molecule might attach simultaneously.
Disease
Known disease associated with this structure: Cerebellar hypoplasia, VLDLR-associated OMIM:[192977]
About this Structure
1V9U is a Protein complex structure of sequences from Homo sapiens and Human rhinovirus 2 with and as ligands. Full crystallographic information is available from OCA.
Reference
X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:15064754
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