2j0o
From Proteopedia
(New page: 200px<br /> <applet load="2j0o" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j0o, resolution 3.0Å" /> '''SHIGELLA FLEXNERI IP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J0O is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0O OCA]]. | + | 2J0O is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0O OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: virulence]] | [[Category: virulence]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:54:49 2007'' |
Revision as of 09:50, 30 October 2007
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SHIGELLA FLEXNERI IPAD
Overview
Bacteria expressing type III secretion systems (T3SS) have been, responsible for the deaths of millions worldwide, acting as key virulence, elements in diseases ranging from plague to typhoid fever. The T3SS is, composed of a basal body, which traverses both bacterial membranes, and an, external needle through which effector proteins are secreted. We report, multiple crystal structures of two proteins that sit at the tip of the, needle and are essential for virulence: IpaD from Shigella flexneri and, BipD from Burkholderia pseudomallei. The structures reveal that the, N-terminal domains of the molecules are intramolecular chaperones that, prevent premature oligomerization, as well as sharing structural homology, with proteins involved in eukaryotic actin rearrangement. Crystal packing, ... [(full description)]
About this Structure
2J0O is a [Single protein] structure of sequence from [Shigella flexneri] with GOL as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD., Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, Lea SM, J Biol Chem. 2007 Feb 9;282(6):4035-44. Epub 2006 Oct 31. PMID:17077085
Page seeded by OCA on Tue Oct 30 11:54:49 2007
Categories: Shigella flexneri | Single protein | Johnson, S. | Lea, S.M. | Roversi, P. | GOL | Cell invasion | Invasin | Ipad | Plasmid | T3ss | Type iii secretion | Virulence
