This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1sb1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sb1.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sb1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sb1| PDB=1sb1 | SCENE= }}
{{STRUCTURE_1sb1| PDB=1sb1 | SCENE= }}
-
'''Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics'''
+
===Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics===
-
==Overview==
+
<!--
-
The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine surrogate are described. Compound 9, the most potent in the series of thrombin inhibitors, exhibited an in vitro K(i) of 128 nM and 342-fold selectivity against trypsin. The binding mode of this novel class of thrombin inhibitors in the enzyme active site, based on the X-ray crystal structure of compound 9 co-crystallized with human alpha-thrombin, is discussed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15051174}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15051174 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15051174}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Thrombin]]
[[Category: Thrombin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:29:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:25:37 2008''

Revision as of 01:25, 29 July 2008

Image:1sb1.png

Template:STRUCTURE 1sb1

Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics

Template:ABSTRACT PUBMED 15051174

About this Structure

1SB1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics., Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D, Eur J Med Chem. 2004 Mar;39(3):257-65. PMID:15051174

Page seeded by OCA on Tue Jul 29 04:25:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sb1"
Personal tools