1sca

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[[Image:1sca.gif|left|200px]]
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{{Seed}}
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[[Image:1sca.png|left|200px]]
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{{STRUCTURE_1sca| PDB=1sca | SCENE= }}
{{STRUCTURE_1sca| PDB=1sca | SCENE= }}
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'''ENZYME CRYSTAL STRUCTURE IN A NEAT ORGANIC SOLVENT'''
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===ENZYME CRYSTAL STRUCTURE IN A NEAT ORGANIC SOLVENT===
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==Overview==
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The crystal structure of the serine protease subtilisin Carlsberg in anhydrous acetonitrile was determined at 2.3 A resolution. It was found to be essentially identical to the three-dimensional structure of the enzyme in water; the differences observed were smaller than those between two independently determined structures in aqueous solution. The hydrogen bond system of the catalytic triad is intact in acetonitrile. The majority (99 of 119) of enzyme-bound, structural water molecules have such a great affinity to subtilisin that they are not displaced even in anhydrous acetonitrile. Of the 12 enzyme-bound acetonitrile molecules, 4 displace water molecules and 8 bind where no water had been observed before. One-third of all subtilisin-bound acetonitrile molecules reside in the active center, occupying the same region (P1, P2, and P3 binding sites) as the specific protein inhibitor eglin c.
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(as it appears on PubMed at http://www.pubmed.gov), where 8378343 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8378343}}
==About this Structure==
==About this Structure==
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[[Category: Steinmetz, A C.U.]]
[[Category: Steinmetz, A C.U.]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:32:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:14:29 2008''

Revision as of 14:14, 27 July 2008

Image:1sca.png

Template:STRUCTURE 1sca

ENZYME CRYSTAL STRUCTURE IN A NEAT ORGANIC SOLVENT

Template:ABSTRACT PUBMED 8378343

About this Structure

1SCA is a Single protein structure of sequence from Bacillus licheniformis. Full crystallographic information is available from OCA.

Reference

Enzyme crystal structure in a neat organic solvent., Fitzpatrick PA, Steinmetz AC, Ringe D, Klibanov AM, Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8653-7. PMID:8378343

Page seeded by OCA on Sun Jul 27 17:14:29 2008

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