1sdb

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{{STRUCTURE_1sdb| PDB=1sdb | SCENE= }}
{{STRUCTURE_1sdb| PDB=1sdb | SCENE= }}
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'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''
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===PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN===
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==Overview==
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Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
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{{ABSTRACT_PUBMED_15299880}}
==About this Structure==
==About this Structure==
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[[Category: Liang, D C.]]
[[Category: Liang, D C.]]
[[Category: Hormone]]
[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:26:48 2008''

Revision as of 08:27, 29 July 2008

Image:1sdb.png

Template:STRUCTURE 1sdb

PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN

Template:ABSTRACT PUBMED 15299880

About this Structure

1SDB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880

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