8qs8

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Current revision (05:13, 23 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8qs8 is ON HOLD until Paper Publication
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==Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378)==
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<StructureSection load='8qs8' size='340' side='right'caption='[[8qs8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Konstantinidou, M., Vickery, H., Pennings, M.A.M., Virta, J., Visser, E.J., Oetelaar, M.C.M., Overmans, M., Neitz, J., Ottmann, C., Brunsveld, L., Arkin, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QS8 FirstGlance]. <br>
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Description: Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=WQN:1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone'>WQN</scene></td></tr>
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[[Category: Neitz, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qs8 OCA], [https://pdbe.org/8qs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qs8 RCSB], [https://www.ebi.ac.uk/pdbsum/8qs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qs8 ProSAT]</span></td></tr>
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[[Category: Oetelaar, M.C.M]]
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</table>
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[[Category: Ottmann, C]]
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== Function ==
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[[Category: Brunsveld, L]]
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[[Category: Vickery, H]]
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__TOC__
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[[Category: Konstantinidou, M]]
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</StructureSection>
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[[Category: Arkin, M.R]]
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[[Category: Homo sapiens]]
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[[Category: Overmans, M]]
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[[Category: Large Structures]]
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[[Category: Pennings, M.A.M]]
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[[Category: Arkin MR]]
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[[Category: Virta, J]]
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[[Category: Brunsveld L]]
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[[Category: Visser, E.J]]
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[[Category: Konstantinidou M]]
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[[Category: Neitz J]]
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[[Category: Oetelaar MCM]]
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[[Category: Ottmann C]]
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[[Category: Overmans M]]
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[[Category: Pennings MAM]]
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[[Category: Vickery H]]
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[[Category: Virta J]]
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[[Category: Visser EJ]]

Current revision

Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378)

PDB ID 8qs8

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OCA

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