1sdl

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[[Image:1sdl.gif|left|200px]]
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{{Seed}}
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[[Image:1sdl.png|left|200px]]
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{{STRUCTURE_1sdl| PDB=1sdl | SCENE= }}
{{STRUCTURE_1sdl| PDB=1sdl | SCENE= }}
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'''CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A'''
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===CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A===
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==Overview==
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The structural end-points of haemoglobin's transition from its low-oxygen-affinity (T) to high-oxygen-affinity (R) state, have been well established by X-ray crystallography, but short-lived intermediates have proved less amenable to X-ray studies. Here we use chemical crosslinking to fix these intermediates for structural characterization. We describe the X-ray structures of three haemoglobins, alpha 2 beta 1S82 beta, alpha 2 beta 1Tm82 beta and alpha 2 beta 1,82Tm82 beta, which were crosslinked between the amino groups of residues beta Val1 and beta Lys82 by 3,3'-stilbenedicarboxylic acid (S) or trimesic acid (Tm) while in the deoxy state, and saturated with carbon monoxide before crystallization. alpha 2 beta 1S82 beta, which has almost normal oxygen affinity, is completely in the R-state conformation; however, alpha 2 beta 1Tm82 beta and alpha 2 beta 1,82Tm82 beta, both of which have low oxygen affinity, have been prevented from completing their transition into the R state and display many features of a transitional intermediate. These haemoglobins therefore represent a snapshot of the nascent R state.
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The line below this paragraph, {{ABSTRACT_PUBMED_7723849}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7723849 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7723849}}
==About this Structure==
==About this Structure==
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[[Category: Polymorphism]]
[[Category: Polymorphism]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:34:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:03:39 2008''

Revision as of 16:03, 28 July 2008

Image:1sdl.png

Template:STRUCTURE 1sdl

CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A

Template:ABSTRACT PUBMED 7723849

About this Structure

1SDL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Allosteric transition intermediates modelled by crosslinked haemoglobins., Schumacher MA, Dixon MM, Kluger R, Jones RT, Brennan RG, Nature. 1995 May 4;375(6526):84-7. PMID:7723849

Page seeded by OCA on Mon Jul 28 19:03:39 2008

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