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1sds

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{{STRUCTURE_1sds| PDB=1sds | SCENE= }}
{{STRUCTURE_1sds| PDB=1sds | SCENE= }}
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'''Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA'''
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===Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA===
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==Overview==
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The archaeal RNA binding protein L7Ae and its eukaryotic homolog 15.5 kDa/Snu13 recognize K-turns. This structural motif is canonically comprised of two stems (one with tandem A.G base pairs, the other with Watson-Crick pairs) linked by an asymmetric internal loop. L7Ae recognizes conventional K-turns in ribosomal and box C/D RNAs but also binds specifically to some box H/ACA RNAs at terminal stem loops. These have the A.G paired stem, but lack the Watson-Crick stem. The structure of Methanococcus jannaschii L7Ae bound to a symmetric duplex RNA without Watson-Crick stems demonstrates how a binding site for this component of diverse ribonucleoprotein complexes can be constructed with only the A.G stem and the loop. The RNA adopts a functional conformation with the aid of a base triple and tight binding of divalent cations. Comparison with the 15.5 kDa/Snu13-RNA complex structure suggests why the eukaryotic homolog does not recognize terminal stem loop L7Ae binding sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_15130481}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15130481 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15130481}}
==About this Structure==
==About this Structure==
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[[Category: Hamma, T.]]
[[Category: Hamma, T.]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:35:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:14:05 2008''

Revision as of 14:14, 28 July 2008

Image:1sds.png

Template:STRUCTURE 1sds

Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA

Template:ABSTRACT PUBMED 15130481

About this Structure

1SDS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution., Hamma T, Ferre-D'Amare AR, Structure. 2004 May;12(5):893-903. PMID:15130481

Page seeded by OCA on Mon Jul 28 17:14:05 2008

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