8vic

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Current revision (08:19, 14 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8vic is ON HOLD until Paper Publication
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==AP-6 bound human TMEM175==
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<StructureSection load='8vic' size='340' side='right'caption='[[8vic]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
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Authors: Oh, S., Hite, R.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8vic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VIC FirstGlance]. <br>
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Description: AP-6 bound human TMEM175
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vic OCA], [https://pdbe.org/8vic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vic RCSB], [https://www.ebi.ac.uk/pdbsum/8vic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vic ProSAT]</span></td></tr>
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[[Category: Hite, R.K]]
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</table>
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[[Category: Oh, S]]
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== Disease ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hite RK]]
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[[Category: Oh S]]

Current revision

AP-6 bound human TMEM175

PDB ID 8vic

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