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1sej

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[[Image:1sej.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1sej| PDB=1sej | SCENE= }}
{{STRUCTURE_1sej| PDB=1sej | SCENE= }}
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'''Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP'''
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===Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP===
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==Overview==
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Cryptosporidium hominis is a protozoan parasite that causes acute gastrointestinal illness. There are no effective therapies for cryptosporidiosis, highlighting the need for new drug-lead discovery. An analysis of the protein-ligand interactions in two crystal structures of dihydrofolate reductase-thymidylate synthase (DHFR-TS) from C. hominis, determined at 2.8 and 2.87 A resolution, reveals that the interactions of residues Ile29, Thr58 and Cys113 in the active site of C. hominis DHFR provide a possible structural basis for the observed antifolate resistance. A comparison with the structure of human DHFR reveals active-site differences that may be exploited for the design of species-selective inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16511011 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16511011}}
==About this Structure==
==About this Structure==
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[[Category: Anderson, A C.]]
[[Category: Anderson, A C.]]
[[Category: Bifunctional enzyme]]
[[Category: Bifunctional enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:36:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:31:53 2008''

Revision as of 12:31, 29 July 2008

Image:1sej.png

Template:STRUCTURE 1sej

Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP

Template:ABSTRACT PUBMED 16511011

About this Structure

1SEJ is a Single protein structure of sequence from Cryptosporidium hominis. Full crystallographic information is available from OCA.

Reference

Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance., Anderson AC, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):258-62. Epub 2005 Feb 8. PMID:16511011

Page seeded by OCA on Tue Jul 29 15:31:53 2008

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