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1sem

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{{STRUCTURE_1sem| PDB=1sem | SCENE= }}
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'''STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS'''
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===STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS===
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==Overview==
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The Src-homology-3 (SH3) domains of the Caenorhabditis elegans protein SEM-5 and its human and Drosophila homologues, Grb2 and Drk (refs 1-4), bind proline-rich sequences found in the nucleotide-exchange factor Sos as part of their proposed function linking receptor tyrosine kinase activation to Ras activation. Here we report the crystal structure at 2.0 A resolution of the carboxy-terminal SH3 domain from SEM-5 complexed to the mSos-derived amino-acid sequence PPPVPPRRR. The peptide is found to bind in an orientation ('minus') that is precisely opposite to that observed previously ('plus' orientation) in other SH3-peptide complexes. This novel ability of peptide-recognition proteins to recognize peptides in two distinct modes may play an important role in the signalling specificity of pathways involving SH3 domains. Comparison of this structure with other SH3 complexes reveals how a conserved binding face can be used to recognize peptides in different orientations, and why the Sos peptide binds in this particular orientation.
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(as it appears on PubMed at http://www.pubmed.gov), where 7802869 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7802869}}
==About this Structure==
==About this Structure==
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[[Category: Guanine nucleotide exchange factor]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Peptide-binding protein]]
[[Category: Peptide-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:36:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:48:56 2008''

Revision as of 09:48, 29 July 2008

Image:1sem.png

Template:STRUCTURE 1sem

STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS

Template:ABSTRACT PUBMED 7802869

About this Structure

1SEM is a Single protein structure of sequence from Caenorhabditis elegans and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains., Lim WA, Richards FM, Fox RO, Nature. 1994 Nov 24;372(6504):375-9. PMID:7802869

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