8xxy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:54, 26 February 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8xxy is ON HOLD
+
==Structure of CXCR3 in the apo-state (Receptor focused map)==
-
 
+
<StructureSection load='8xxy' size='340' side='right'caption='[[8xxy]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
-
Authors: Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8xxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XXY FirstGlance]. <br>
-
Description: Structure of CXCR3 in the apo-state (Receptor focused map)
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xxy OCA], [https://pdbe.org/8xxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xxy RCSB], [https://www.ebi.ac.uk/pdbsum/8xxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xxy ProSAT]</span></td></tr>
-
[[Category: Nureki, O]]
+
</table>
-
[[Category: Shihoya, W]]
+
== Function ==
-
[[Category: Banerjee, R]]
+
[https://www.uniprot.org/uniprot/CXCR3_HUMAN CXCR3_HUMAN] Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.<ref>PMID:12782716</ref> <ref>PMID:18174362</ref> <ref>PMID:24469069</ref> Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.<ref>PMID:12782716</ref> Mediates the activity of CXCL11.
-
[[Category: Saha, S]]
+
== References ==
-
[[Category: Shukla, A.K]]
+
<references/>
-
[[Category: Sano, F.K]]
+
__TOC__
-
[[Category: Ganguly, M]]
+
</StructureSection>
-
[[Category: Sharma, S]]
+
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Banerjee R]]
 +
[[Category: Ganguly M]]
 +
[[Category: Nureki O]]
 +
[[Category: Saha S]]
 +
[[Category: Sano FK]]
 +
[[Category: Sharma S]]
 +
[[Category: Shihoya W]]
 +
[[Category: Shukla AK]]

Current revision

Structure of CXCR3 in the apo-state (Receptor focused map)

PDB ID 8xxy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8xxy"
Personal tools