1sf8

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[[Image:1sf8.gif|left|200px]]
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{{Seed}}
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[[Image:1sf8.png|left|200px]]
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{{STRUCTURE_1sf8| PDB=1sf8 | SCENE= }}
{{STRUCTURE_1sf8| PDB=1sf8 | SCENE= }}
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'''Crystal structure of the carboxy-terminal domain of htpG, the E. coli Hsp90'''
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===Crystal structure of the carboxy-terminal domain of htpG, the E. coli Hsp90===
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==Overview==
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Hsp90 is a ubiquitous, well-conserved molecular chaperone involved in the folding and stabilization of diverse proteins. Beyond its capacity for general protein folding, Hsp90 influences a wide array of cellular signaling pathways that underlie key biological and disease processes. It has been proposed that Hsp90 functions as a molecular clamp, dimerizing through its carboxy-terminal domain and utilizing ATP binding and hydrolysis to drive large conformational changes including transient dimerization of the amino-terminal and middle domains. We have determined the 2.6 A X-ray crystal structure of the carboxy-terminal domain of htpG, the Escherichia coli Hsp90. This structure reveals a novel fold and that dimerization is dependent upon the formation of a four-helix bundle. Remarkably, proximal to the helical dimerization motif, each monomer projects a short helix into solvent. The location, flexibility, and amphipathic character of this helix suggests that it may play a role in substrate binding and hence chaperone activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_15274928}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15274928 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274928}}
==About this Structure==
==About this Structure==
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[[Category: Four helix bundle dimerization interface]]
[[Category: Four helix bundle dimerization interface]]
[[Category: Three stranded beta sheet]]
[[Category: Three stranded beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:37:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:32:06 2008''

Revision as of 18:32, 28 July 2008

Image:1sf8.png

Template:STRUCTURE 1sf8

Crystal structure of the carboxy-terminal domain of htpG, the E. coli Hsp90

Template:ABSTRACT PUBMED 15274928

About this Structure

1SF8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site., Harris SF, Shiau AK, Agard DA, Structure. 2004 Jun;12(6):1087-97. PMID:15274928

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