1sfi

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[[Image:1sfi.gif|left|200px]]
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{{Seed}}
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[[Image:1sfi.png|left|200px]]
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{{STRUCTURE_1sfi| PDB=1sfi | SCENE= }}
{{STRUCTURE_1sfi| PDB=1sfi | SCENE= }}
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'''HIGH RESOLUTION STRUCTURE OF A POTENT, CYCLIC PROTEASE INHIBITOR FROM SUNFLOWER SEEDS'''
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===HIGH RESOLUTION STRUCTURE OF A POTENT, CYCLIC PROTEASE INHIBITOR FROM SUNFLOWER SEEDS===
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==Overview==
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Proteinaceous serine proteinase inhibitors are widespread throughout the plant kingdom where they play an important role in protection against pests and pathogens. Here, we describe the isolation and characterisation of a novel 14 amino acid residue cyclic peptide from sunflower seeds, which is a potent inhibitor of trypsin (Ki=100 pM). The crystal structure of this peptide in complex with bovine beta-trypsin shows both sequence and conformational similarity with the trypsin-reactive loop of the Bowman-Birk family of serine proteinase inhibitors. This inhibitor, however, is unique in being monofunctional, cyclic and far shorter (14 amino acid residues) than inhibitors belonging to this family (typically 60-70 amino acid residues). The high potency of this peptide is likely to arise from the considerable structural rigidity achieved through its cyclic nature which is further stabilised by a single internal disulphide bond. This study helps delineate the minimal unit required for effective peptide inhibitors of serine proteinases, and will assist in the further design of inhibitors to this widespread class of enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_10390350}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10390350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10390350}}
==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Trypsin inhibitor]]
[[Category: Trypsin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:38:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:36:21 2008''

Revision as of 06:36, 29 July 2008

Image:1sfi.png

Template:STRUCTURE 1sfi

HIGH RESOLUTION STRUCTURE OF A POTENT, CYCLIC PROTEASE INHIBITOR FROM SUNFLOWER SEEDS

Template:ABSTRACT PUBMED 10390350

About this Structure

1SFI is a Single protein structure of sequence from Bos taurus and Helianthus annuus. Full crystallographic information is available from OCA.

Reference

High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds., Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL, J Mol Biol. 1999 Jul 9;290(2):525-33. PMID:10390350

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