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1sfu

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{{STRUCTURE_1sfu| PDB=1sfu | SCENE= }}
{{STRUCTURE_1sfu| PDB=1sfu | SCENE= }}
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'''Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA'''
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===Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA===
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==Overview==
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A conserved feature of poxviruses is a protein, well characterized as E3L in vaccinia virus, that confers IFN resistance on the virus. This protein comprises two domains, an N-terminal Z-DNA-binding protein domain (Zalpha) and a C-terminal double-stranded RNA-binding domain. Both are required for pathogenicity of vaccinia virus in mice infected by intracranial injection. Here, we describe the crystal structure of the Zalpha domain from the E3L-like protein of Yaba-like disease virus, a Yatapoxvirus, in a complex with Z-DNA, solved at a 2.0-A resolution. The DNA contacting surface of Yaba-like disease virus Zalpha(E3L) closely resembles that of other structurally defined members of the Zalpha family, although some variability exists in the beta-hairpin region. In contrast to the Z-DNA-contacting surface, the nonbinding surface of members of the Zalpha family are unrelated; this surface may effect protein-specific interactions. The presence of the conserved and tailored Z-DNA-binding surface, which interacts specifically with the zigzag backbone and syn base diagnostic of the Z-form, reinforces the importance to poxvirus infection of the ability of this protein to recognize the Z-conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 15448208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15448208}}
==About this Structure==
==About this Structure==
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[[Category: Wu, C A.]]
[[Category: Wu, C A.]]
[[Category: Protein/z-dna complex]]
[[Category: Protein/z-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:39:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:18:05 2008''

Revision as of 03:18, 28 July 2008

Image:1sfu.png

Template:STRUCTURE 1sfu

Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA

Template:ABSTRACT PUBMED 15448208

About this Structure

1SFU is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.

Reference

A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA., Ha SC, Lokanath NK, Van Quyen D, Wu CA, Lowenhaupt K, Rich A, Kim YG, Kim KK, Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14367-72. Epub 2004 Sep 24. PMID:15448208

Page seeded by OCA on Mon Jul 28 06:18:05 2008

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