1sfy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sfy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sfy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sfy| PDB=1sfy | SCENE= }}
{{STRUCTURE_1sfy| PDB=1sfy | SCENE= }}
-
'''Crystal structure of recombinant Erythrina corallodandron Lectin'''
+
===Crystal structure of recombinant Erythrina corallodandron Lectin===
-
==Overview==
+
<!--
-
The three-dimensional structure of the recombinant form of Erythrina corallodendron lectin, complexed with lactose, has been elucidated by X-ray crystallography at 2.55 A resolution. Comparison of this non-glycosylated structure with that of the native glycosylated lectin reveals that the tertiary and quaternary structures are identical in the two forms, with local changes observed at one of the glycosylation sites (Asn17). These changes take place in such a way that hydrogen bonds with the neighboring protein molecules in rECorL compensate those made by the glycan with the protein in ECorL. Contrary to an earlier report, this study demonstrates that the glycan attached to the lectin does not influence the oligomeric state of the lectin. Identical interactions between the lectin and the non-covalently bound lactose in the two forms indicate, in line with earlier reports, that glycosylation does not affect the carbohydrate specificity of the lectin. The present study, the first of its kind involving a glycosylated protein with a well-defined glycan and the corresponding deglycosylated form, provides insights into the structural aspects of protein glycosylation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15281133}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15281133 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15281133}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Glycosylation]]
[[Category: Glycosylation]]
[[Category: Legume lectin]]
[[Category: Legume lectin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:39:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:44:16 2008''

Revision as of 12:44, 28 July 2008

Image:1sfy.png

Template:STRUCTURE 1sfy

Crystal structure of recombinant Erythrina corallodandron Lectin

Template:ABSTRACT PUBMED 15281133

About this Structure

1SFY is a Single protein structure of sequence from Erythrina corallodendron. Full crystallographic information is available from OCA.

Reference

Effect of glycosylation on the structure of Erythrina corallodendron lectin., Kulkarni KA, Srivastava A, Mitra N, Sharon N, Surolia A, Vijayan M, Suguna K, Proteins. 2004 Sep 1;56(4):821-7. PMID:15281133

Page seeded by OCA on Mon Jul 28 15:44:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sfy"
Personal tools