9f1k

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Current revision (06:13, 11 September 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9f1k is ON HOLD
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==First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30==
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<StructureSection load='9f1k' size='340' side='right'caption='[[9f1k]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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Authors: Balourdas, D.I., Edmonds, A.K., Marsh, G.P., Maple, H.J., Spencer, J., Knapp, S., Joerger, A.C., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9f1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F1K FirstGlance]. <br>
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Description: First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f1k OCA], [https://pdbe.org/9f1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f1k RCSB], [https://www.ebi.ac.uk/pdbsum/9f1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f1k ProSAT]</span></td></tr>
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[[Category: Balourdas, D.I]]
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</table>
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[[Category: Knapp, S]]
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== Disease ==
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[[Category: Joerger, A.C]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[[Category: Marsh, G.P]]
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== Function ==
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[[Category: Edmonds, A.K]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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[[Category: Spencer, J]]
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<references/>
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[[Category: Maple, H.J]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Balourdas DI]]
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[[Category: Edmonds AK]]
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[[Category: Joerger AC]]
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[[Category: Knapp S]]
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[[Category: Maple HJ]]
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[[Category: Marsh GP]]
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[[Category: Spencer J]]

Current revision

First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30

PDB ID 9f1k

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OCA

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