1shc

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{{STRUCTURE_1shc| PDB=1shc | SCENE= }}
{{STRUCTURE_1shc| PDB=1shc | SCENE= }}
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'''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.
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{{ABSTRACT_PUBMED_8524391}}
==About this Structure==
==About this Structure==
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1SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].
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1SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].
==Reference==
==Reference==
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[[Category: Wade, W S.]]
[[Category: Wade, W S.]]
[[Category: Zhou, M M.]]
[[Category: Zhou, M M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:42:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:06:42 2008''

Revision as of 12:06, 27 July 2008

Image:1shc.png

Template:STRUCTURE 1shc

SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8524391

About this Structure

1SHC is a Protein complex structure of sequences from Escherichia coli. Full experimental information is available from OCA.

Reference

Structure and ligand recognition of the phosphotyrosine binding domain of Shc., Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW, Nature. 1995 Dec 7;378(6557):584-92. PMID:8524391

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