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1sje

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[[Image:1sje.gif|left|200px]]
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{{Seed}}
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[[Image:1sje.png|left|200px]]
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{{STRUCTURE_1sje| PDB=1sje | SCENE= }}
{{STRUCTURE_1sje| PDB=1sje | SCENE= }}
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'''HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation'''
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===HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation===
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==Overview==
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T cells generally recognize peptide antigens bound to MHC proteins through contacts with residues found within or immediately flanking the seven- to nine-residue sequence accommodated in the MHC peptide-binding groove. However, some T cells require peptide residues outside this region for activation, the structural basis for which is unknown. Here, we have investigated a HIV Gag-specific T cell clone that requires an unusually long peptide antigen for activation. The crystal structure of a minimally antigenic 16-mer bound to HLA-DR1 shows that the peptide C-terminal region bends sharply into a hairpin turn as it exits the binding site, orienting peptide residues outside the MHC-binding region in position to interact with a T cell receptor. Peptide truncation and substitution studies show that both the hairpin turn and the extreme C-terminal residues are required for T cell activation. These results demonstrate a previously unrecognized mode of MHC-peptide-T cell receptor interaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_15331779}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15331779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15331779}}
==About this Structure==
==About this Structure==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Superantigen]]
[[Category: Superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:46:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:11:40 2008''

Revision as of 01:11, 29 July 2008

Image:1sje.png

Template:STRUCTURE 1sje

HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation

Template:ABSTRACT PUBMED 15331779

About this Structure

1SJE is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition., Zavala-Ruiz Z, Strug I, Walker BD, Norris PJ, Stern LJ, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13279-84. Epub 2004 Aug 26. PMID:15331779

Page seeded by OCA on Tue Jul 29 04:11:40 2008

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