1sjr

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[[Image:1sjr.gif|left|200px]]
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{{STRUCTURE_1sjr| PDB=1sjr | SCENE= }}
{{STRUCTURE_1sjr| PDB=1sjr | SCENE= }}
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'''NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)'''
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===NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)===
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==Overview==
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The polypyrimidine tract binding protein (PTB) is an important regulator of alternative splicing that also affects mRNA localization, stabilization, polyadenylation, and translation. NMR structural analysis of the N-terminal half of PTB (residues 55-301) shows a canonical structure for RRM1 but reveals novel extensions to the beta strands and C terminus of RRM2 that significantly modify the beta sheet RNA binding surface. Although PTB contains four RNA recognition motifs (RRMs), it is widely held that only RRMs 3 and 4 are involved in RNA binding and that RRM2 mediates homodimerization. However, we show here not only that the RRMs 1 and 2 contribute substantially to RNA binding but also that full-length PTB is monomeric, with an elongated structure determined by X-ray solution scattering that is consistent with a linear arrangement of the constituent RRMs. These new insights into the structure and RNA binding properties of PTB suggest revised models of its mechanism of action.
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{{ABSTRACT_PUBMED_15341728}}
==About this Structure==
==About this Structure==
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1SJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJR OCA].
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1SJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJR OCA].
==Reference==
==Reference==
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[[Category: Tyzack, J K.]]
[[Category: Tyzack, J K.]]
[[Category: Extended babbab motif]]
[[Category: Extended babbab motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:47:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:37:13 2008''

Revision as of 06:37, 28 July 2008

Image:1sjr.png

Template:STRUCTURE 1sjr

NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)

Template:ABSTRACT PUBMED 15341728

About this Structure

1SJR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and RNA interactions of the N-terminal RRM domains of PTB., Simpson PJ, Monie TP, Szendroi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, Curry S, Matthews S, Structure. 2004 Sep;12(9):1631-43. PMID:15341728

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