1w4r
From Proteopedia
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| - | [[Image:1w4r.gif|left|200px]]<br /> | + | [[Image:1w4r.gif|left|200px]]<br /><applet load="1w4r" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1w4r" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1w4r, resolution 1.83Å" /> | caption="1w4r, resolution 1.83Å" /> | ||
'''STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP'''<br /> | '''STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, TTP and DTU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] | + | 1W4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, TTP and DTU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Known structural/functional Site: <scene name='pdbsite=AC1:Dtu Binding Site For Chain E'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: type ii]] | [[Category: type ii]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:30:17 2007'' |
Revision as of 16:20, 18 December 2007
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STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP
Overview
The structure of human cytosolic thymidine kinase in complex with its, feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This, structure is the first representative of the type II thymidine kinases, found in several pathogens. The structure deviates strongly from the known, structures of type I thymidine kinases such as the Herpes simplex enzyme., It contains a zinc-binding domain with four cysteines complexing a, structural zinc ion. Interestingly, the backbone atoms of the type II, enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side, chains are involved. This results in a specificity difference exploited, for antiviral therapy. The presented structure will foster the development, of new drugs and prodrugs for numerous therapeutic applications.
About this Structure
1W4R is a Single protein structure of sequence from Homo sapiens with ZN, TTP and DTU as ligands. Active as Thymidine kinase, with EC number 2.7.1.21 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844
Page seeded by OCA on Tue Dec 18 18:30:17 2007
Categories: Homo sapiens | Single protein | Thymidine kinase | Birringer, M.S. | Claus, M.T. | Folkers, G. | Kloer, D.P. | Scapozza, L. | Schulz, G.E. | DTU | TTP | ZN | Cytosolic | Human | Kinase | Phosphorylation | Transferase | Type ii
