8zl1

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Current revision (06:21, 29 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8zl1 is ON HOLD until Paper Publication
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==Cryo-EM structure of the Drosophila INDY (apo outward-open, pH 6)==
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<StructureSection load='8zl1' size='340' side='right'caption='[[8zl1]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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Authors: Kim, S., Park, J.G., Choi, S.H., Kim, J.W., Jin, M.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZL1 FirstGlance]. <br>
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Description: Cryo-EM structure of the Drosophila INDY (apo outward-open, pH 6)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
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[[Category: Kim, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zl1 OCA], [https://pdbe.org/8zl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zl1 RCSB], [https://www.ebi.ac.uk/pdbsum/8zl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zl1 ProSAT]</span></td></tr>
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[[Category: Jin, M.S]]
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</table>
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[[Category: Choi, S.H]]
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== Function ==
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[[Category: Park, J.G]]
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[https://www.uniprot.org/uniprot/INDY1_DROME INDY1_DROME] Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.<ref>PMID:11118146</ref> <ref>PMID:12186628</ref> <ref>PMID:12391301</ref>
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[[Category: Kim, J.W]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
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[[Category: Choi SH]]
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[[Category: Jin MS]]
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[[Category: Kim JW]]
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[[Category: Kim S]]
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[[Category: Park JG]]

Current revision

Cryo-EM structure of the Drosophila INDY (apo outward-open, pH 6)

PDB ID 8zl1

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OCA

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