9bfj

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Current revision (08:14, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9bfj is ON HOLD until Paper Publication
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==Cryo-EM structure of human CHT1 in the choline bound state==
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<StructureSection load='9bfj' size='340' side='right'caption='[[9bfj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9bfj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BFJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bfj OCA], [https://pdbe.org/9bfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bfj RCSB], [https://www.ebi.ac.uk/pdbsum/9bfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bfj ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SC5A7_HUMAN SC5A7_HUMAN] Distal hereditary motor neuropathy type 7;Presynaptic congenital myasthenic syndromes. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SC5A7_HUMAN SC5A7_HUMAN] High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11027560, PubMed:11068039, PubMed:12237312, PubMed:12969261, PubMed:17005849, PubMed:23132865, PubMed:23141292, PubMed:27569547). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (PubMed:17005849). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (PubMed:11068039, PubMed:12237312, PubMed:17005849). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (PubMed:27569547). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11027560). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (PubMed:12969261, PubMed:15953352).<ref>PMID:11027560</ref> <ref>PMID:11068039</ref> <ref>PMID:12237312</ref> <ref>PMID:12969261</ref> <ref>PMID:15953352</ref> <ref>PMID:17005849</ref> <ref>PMID:23132865</ref> <ref>PMID:23141292</ref> <ref>PMID:27569547</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jiang Y]]
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[[Category: Xue J]]

Current revision

Cryo-EM structure of human CHT1 in the choline bound state

PDB ID 9bfj

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OCA

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