1sl8

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{{STRUCTURE_1sl8| PDB=1sl8 | SCENE= }}
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'''Calcium-loaded apo-aequorin from Aequorea victoria'''
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===Calcium-loaded apo-aequorin from Aequorea victoria===
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==Overview==
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The crystal structures of calcium-loaded apo-aequorin and apo-obelin have been determined at resolutions 1.7A and 2.2 A, respectively. A calcium ion is observed in each of the three EF-hand loops that have the canonical calcium-binding sequence, and each is coordinated in the characteristic pentagonal bipyramidal configuration. The calcium-loaded apo-protein retain the same compact scaffold and overall fold as the unreacted photoproteins containing the bound substrate, 2-hyroperoxycoelenterazine, and also the same as the Ca2+-discharged obelin bound with product, coleneteramide. Nevertheless, there are easily discerned shifts in both helix and loop regions, and the shifts are not the same between the two proteins. It is suggested that these photoproteins to sense Ca2+ concentration transients and to produce their bioluminescence response on the millisecond timescale. A mechanism of intrastructural transmission of the calcium signal is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15689515 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15689515}}
==About this Structure==
==About this Structure==
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[[Category: Southeast collaboratory for structural genomic]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:50:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:29:58 2008''

Revision as of 05:29, 28 July 2008

Image:1sl8.png

Template:STRUCTURE 1sl8

Calcium-loaded apo-aequorin from Aequorea victoria

Template:ABSTRACT PUBMED 15689515

About this Structure

1SL8 is a Single protein structure of sequence from Aequorea victoria. Full crystallographic information is available from OCA.

Reference

All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin., Deng L, Vysotski ES, Markova SV, Liu ZJ, Lee J, Rose J, Wang BC, Protein Sci. 2005 Mar;14(3):663-75. Epub 2005 Feb 2. PMID:15689515

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