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1smd

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[[Image:1smd.gif|left|200px]]
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==Overview==
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{{ABSTRACT_15299664}}
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Salivary alpha-amylase, a major component of human saliva, plays a role in the initial digestion of starch and may be involved in the colonization of bacteria involved in early dental plaque formation. The three-dimensional atomic structure of salivary amylase has been determined to understand the structure-function relationships of this enzyme. This structure was refined to an R value of 18.4% with 496 amino-acid residues, one calcium ion, one chloride ion and 170 water molecules. Salivary amylase folds into a multidomain structure consisting of three domains, A, B and C. Domain A has a (beta/alpha)(8-) barrel structure, domain B has no definite topology and domain C has a Greek-key barrel structure. The Ca(2+) ion is bound to Asnl00, Arg158, Asp167, His201 and three water molecules. The Cl(-) ion is bound to Arg195, Asn298 and Arg337 and one water molecule. The highly mobile glycine-rich loop 304-310 may act as a gateway for substrate binding and be involved in a 'trap-release' mechanism in the hydrolysis of substrates. Strategic placement of calcium and chloride ions, as well as histidine and tryptophan residues may play a role in differentiating between the glycone and aglycone ends of the polysaccharide substrates. Salivary amylase also possesses a suitable site for binding to enamel surfaces and provides potential sites for the binding of bacterial adhesins.
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==About this Structure==
==About this Structure==
1SMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1SMD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb74_1.html Alpha-amylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMD OCA].
1SMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1SMD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb74_1.html Alpha-amylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMD OCA].
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==Reference==
 
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Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity., Ramasubbu N, Paloth V, Luo Y, Brayer GD, Levine MJ, Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):435-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299664 15299664]
 
[[Category: Alpha-amylase]]
[[Category: Alpha-amylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: O-glycosyl]]
[[Category: O-glycosyl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:53:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:57:59 2008''

Revision as of 14:57, 26 June 2008

Image:1smd.png

Template:STRUCTURE 1smd

HUMAN SALIVARY AMYLASE


Template:ABSTRACT 15299664

About this Structure

1SMD is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1SMD with [Alpha-amylase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:57:59 2008

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