1smg

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[[Image:1smg.gif|left|200px]]
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{{STRUCTURE_1smg| PDB=1smg | SCENE= }}
{{STRUCTURE_1smg| PDB=1smg | SCENE= }}
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'''CALCIUM-BOUND E41A MUTANT OF THE N-DOMAIN OF CHICKEN TROPONIN C, NMR, 40 STRUCTURES'''
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===CALCIUM-BOUND E41A MUTANT OF THE N-DOMAIN OF CHICKEN TROPONIN C, NMR, 40 STRUCTURES===
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==Overview==
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The structural transition in troponin C induced by the binding of two calcium ions involves an "opening" of the structure, an event that triggers skeletal muscle contraction. We have solved the solution structure of a mutant (E41A) of the regulatory domain of skeletal troponin C wherein one bidentate ligand to the calcium in site I is missing. This structure remains "closed" upon calcium binding, indicating that the linkage between calcium binding and the induced conformational change has been broken. This provides a snapshot of skeletal troponin C between the off and on state and thereby valuable insight into the mechanism of regulation within skeletal TnC. Although several factors contribute to the triggering mechanism, the opening of the troponin C structure is ultimately dependent on one amino acid, Glu41. Insights into the structure of cardiac troponin C can also be derived from this skeletal mutant.
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(as it appears on PubMed at http://www.pubmed.gov), where 9109645 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9109645}}
==About this Structure==
==About this Structure==
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1SMG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMG OCA].
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1SMG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMG OCA].
==Reference==
==Reference==
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[[Category: Muscle protein]]
[[Category: Muscle protein]]
[[Category: Troponin c]]
[[Category: Troponin c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:53:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:14:56 2008''

Revision as of 02:14, 29 July 2008

Image:1smg.png

Template:STRUCTURE 1smg

CALCIUM-BOUND E41A MUTANT OF THE N-DOMAIN OF CHICKEN TROPONIN C, NMR, 40 STRUCTURES

Template:ABSTRACT PUBMED 9109645

About this Structure

1SMG is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins., Gagne SM, Li MX, Sykes BD, Biochemistry. 1997 Apr 15;36(15):4386-92. PMID:9109645

Page seeded by OCA on Tue Jul 29 05:14:56 2008

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