1smo

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{{STRUCTURE_1smo| PDB=1smo | SCENE= }}
{{STRUCTURE_1smo| PDB=1smo | SCENE= }}
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'''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .'''
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===Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .===
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==Overview==
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The triggering receptor expressed on myeloid cells (TREM) family of single extracellular immunoglobulin receptors includes both activating and inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies the Toll-like receptor initiated responses to invading pathogens allowing the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1 amplifies the inflammation induced by both bacteria and fungi, and thus represents a potential therapeutic target. We report the crystal structure of the human TREM-1 extracellular domain at 1.47 A resolution. The overall fold places it within the V-type immunoglobulin domain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other activating receptors, such as NKp44. With the additional use of analytical ultracentrifugation and 1H NMR spectroscopy of both human and mouse TREM-1, we have conclusively demonstrated the monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general.
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The line below this paragraph, {{ABSTRACT_PUBMED_15351648}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15351648 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15351648}}
==About this Structure==
==About this Structure==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Trem-1]]
[[Category: Trem-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:53:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:37:35 2008''

Revision as of 18:37, 28 July 2008

Image:1smo.png

Template:STRUCTURE 1smo

Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .

Template:ABSTRACT PUBMED 15351648

About this Structure

1SMO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:15351648

Page seeded by OCA on Mon Jul 28 21:37:35 2008

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