1smz

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{{Seed}}
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{{STRUCTURE_1smz| PDB=1smz | SCENE= }}
{{STRUCTURE_1smz| PDB=1smz | SCENE= }}
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'''Structure of Transportan in phospholipid bicellar solution'''
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===Structure of Transportan in phospholipid bicellar solution===
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==Overview==
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Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.
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The line below this paragraph, {{ABSTRACT_PUBMED_15178334}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15178334 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15178334}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA].
==Reference==
==Reference==
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[[Category: Maler, L.]]
[[Category: Maler, L.]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:54:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:03:19 2008''

Revision as of 03:03, 29 July 2008

Image:1smz.png

Template:STRUCTURE 1smz

Structure of Transportan in phospholipid bicellar solution

Template:ABSTRACT PUBMED 15178334

About this Structure

Full experimental information is available from OCA.

Reference

NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334

Page seeded by OCA on Tue Jul 29 06:03:19 2008

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