8zdb

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Current revision (06:20, 12 February 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8zdb is ON HOLD until Paper Publication
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==Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3==
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<StructureSection load='8zdb' size='340' side='right'caption='[[8zdb]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zdb]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZDB FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zdb OCA], [https://pdbe.org/8zdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zdb RCSB], [https://www.ebi.ac.uk/pdbsum/8zdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zdb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSSA_HUMAN RSSA_HUMAN] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.<ref>PMID:6300843</ref> <ref>PMID:16263087</ref> <ref>PMID:15516338</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Beckmann R]]
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[[Category: Cheng J]]
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[[Category: Huang Z]]
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[[Category: Li Y]]
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[[Category: Wang M]]

Current revision

Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3

PDB ID 8zdb

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OCA

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