1sn5

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{{STRUCTURE_1sn5| PDB=1sn5 | SCENE= }}
{{STRUCTURE_1sn5| PDB=1sn5 | SCENE= }}
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'''Crystal Structure of Sea Bream Transthyretin in complex with Triiodothyronine at 1.90A Resolution'''
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===Crystal Structure of Sea Bream Transthyretin in complex with Triiodothyronine at 1.90A Resolution===
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==Overview==
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Transthyretin (TTR) is an extracellular transport protein involved in the distribution of thyroid hormones and vitamin A. So far, TTR has only been found in vertebrates, of which piscine TTR displays the lowest sequence identity with human TTR (47%). Human and piscine TTR bind both thyroid hormones 3,5,3'-triiodo-l-thyronine (T(3)) and 3,5,3',5'-tetraiodo-l-thyronine (thyroxine, T(4)). Human TTR has higher affinity for T(4) than T(3), whereas the reverse holds for piscine TTR. X-ray structures of Sparus aurata (sea bream) TTR have been determined as the apo-protein at 1.75 A resolution and bound to ligands T(3) and T(4), both at 1.9 A resolution. The apo structure is similar to human TTR with structural changes only at beta-strand D. This strand forms an extended loop conformation similar to the one in chicken TTR. The piscine TTR.T(4) complex shows the T(4)-binding site to be similar but not identical to human TTR, whereas the TTR.T(3) complex shows the I3' halogen situated at the site normally occupied by the hydroxyl group of T(4). The significantly wider entrance of the hormone-binding channel in sea bream TTR, in combination with its narrower cavity, provides a structural explanation for the different binding affinities of human and piscine TTR to T(3) and T(4).
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(as it appears on PubMed at http://www.pubmed.gov), where 15082720 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15082720}}
==About this Structure==
==About this Structure==
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[[Category: Sauer-Eriksson, A E.]]
[[Category: Sauer-Eriksson, A E.]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:20:53 2008''

Revision as of 13:20, 27 July 2008

Image:1sn5.png

Template:STRUCTURE 1sn5

Crystal Structure of Sea Bream Transthyretin in complex with Triiodothyronine at 1.90A Resolution

Template:ABSTRACT PUBMED 15082720

About this Structure

1SN5 is a Single protein structure of sequence from Sparus aurata. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine., Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE, J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. PMID:15082720

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