1sn9

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[[Image:1sn9.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1sn9| PDB=1sn9 | SCENE= }}
{{STRUCTURE_1sn9| PDB=1sn9 | SCENE= }}
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'''An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein'''
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===An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein===
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==Overview==
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The x-ray crystal structure of an oligomeric miniprotein has been determined to a 1.2-A resolution by means of multiwavelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical characteristics of the native peptide. Peptide 1, comprising alpha and beta secondary structure elements with only 21 aa per monomer, associates as a discrete tetramer. The peptide adopts a previously uncharacterized quaternary structure in which alpha and beta components interact to form a tightly packed and well defined hydrophobic core. The structure provides insight into the origins of the unusual thermal stability of the oligomer. The miniprotein shares many characteristics of larger proteins, including cooperative folding, lack of 1-anilino-8-naphthalene sulfonate binding, and limited deuterium exchange, and possesses a buried surface area typical of native proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15302930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15302930}}
==About this Structure==
==About this Structure==
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[[Category: Oligomerization]]
[[Category: Oligomerization]]
[[Category: Protein design]]
[[Category: Protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:54:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:43:52 2008''

Revision as of 16:43, 27 July 2008

Image:1sn9.png

Template:STRUCTURE 1sn9

An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein

Template:ABSTRACT PUBMED 15302930

About this Structure

Full crystallographic information is available from OCA.

Reference

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture., Ali MH, Peisach E, Allen KN, Imperiali B, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:15302930

Page seeded by OCA on Sun Jul 27 19:43:52 2008

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