9fi9

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Current revision (04:05, 5 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9fi9 is ON HOLD until Paper Publication
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==Human PIF + Z48847594 (OCCUPANCY 0.7)==
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<StructureSection load='9fi9' size='340' side='right'caption='[[9fi9]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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Authors: Bax, B.D., Sanders, C.M., Antson, A.A., Brandao-Neto, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9fi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FI9 FirstGlance]. <br>
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Description: Human PIF + Z48847594 (OCCUPANCY 0.7)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.727&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=O0J:~{N}-[4-(2-azanyl-1,3-thiazol-4-yl)phenyl]ethanamide'>O0J</scene></td></tr>
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[[Category: Brandao-Neto, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fi9 OCA], [https://pdbe.org/9fi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fi9 RCSB], [https://www.ebi.ac.uk/pdbsum/9fi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fi9 ProSAT]</span></td></tr>
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[[Category: Sanders, C.M]]
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</table>
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[[Category: Bax, B.D]]
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== Function ==
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[[Category: Antson, A.A]]
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[https://www.uniprot.org/uniprot/PIF1_HUMAN PIF1_HUMAN] DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.[HAMAP-Rule:MF_03176]<ref>PMID:16522649</ref> <ref>PMID:17172855</ref> <ref>PMID:17827721</ref> <ref>PMID:18835853</ref> <ref>PMID:19700773</ref> <ref>PMID:20524933</ref> <ref>PMID:23657261</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Antson AA]]
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[[Category: Bax BD]]
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[[Category: Brandao-Neto J]]
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[[Category: Sanders CM]]

Current revision

Human PIF + Z48847594 (OCCUPANCY 0.7)

PDB ID 9fi9

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