9flo

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m (Protected "9flo" [edit=sysop:move=sysop])
Current revision (06:14, 11 September 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9flo is ON HOLD
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==Crystal structure of human Haspin (GSG2) kinase bound to MU2181==
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<StructureSection load='9flo' size='340' side='right'caption='[[9flo]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Kraemer, A., Paruch, K., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9flo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FLO FirstGlance]. <br>
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Description: Crystal structure of human Haspin (GSG2) kinase bound to MU2181
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9flo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9flo OCA], [https://pdbe.org/9flo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9flo RCSB], [https://www.ebi.ac.uk/pdbsum/9flo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9flo ProSAT]</span></td></tr>
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[[Category: Paruch, K]]
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</table>
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[[Category: Kraemer, A]]
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== Function ==
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[[Category: Knapp, S]]
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Knapp S]]
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[[Category: Kraemer A]]
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[[Category: Paruch K]]

Current revision

Crystal structure of human Haspin (GSG2) kinase bound to MU2181

PDB ID 9flo

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OCA

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