1so8

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[[Image:1so8.gif|left|200px]]
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{{Seed}}
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[[Image:1so8.png|left|200px]]
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{{STRUCTURE_1so8| PDB=1so8 | SCENE= }}
{{STRUCTURE_1so8| PDB=1so8 | SCENE= }}
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'''Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]'''
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===Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]===
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==Overview==
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Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial deformation of the active site that prevents nicotinamide adenine dinucleotide (NAD) binding. An ABAD peptide specifically inhibits ABAD-Abeta interaction and suppresses Abeta-induced apoptosis and free-radical generation in neurons. Transgenic mice overexpressing ABAD in an Abeta-rich environment manifest exaggerated neuronal oxidative stress and impaired memory. These data suggest that the ABAD-Abeta interaction may be a therapeutic target in AD.
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The line below this paragraph, {{ABSTRACT_PUBMED_15087549}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15087549 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15087549}}
==About this Structure==
==About this Structure==
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[[Category: Alcohol dehydrogenase]]
[[Category: Alcohol dehydrogenase]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:56:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:27:49 2008''

Revision as of 18:27, 27 July 2008

Image:1so8.png

Template:STRUCTURE 1so8

Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]

Template:ABSTRACT PUBMED 15087549

About this Structure

1SO8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease., Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H, Science. 2004 Apr 16;304(5669):448-52. PMID:15087549

Page seeded by OCA on Sun Jul 27 21:27:49 2008

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