9bqc

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Current revision (06:08, 25 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9bqc is ON HOLD until Paper Publication
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==Human Topoisomerase 2 Beta ATPase domain bound to obex 5c and non-hydrolyzable ATP analog AMPPNP==
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<StructureSection load='9bqc' size='340' side='right'caption='[[9bqc]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9bqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BQC FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ASE:8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-(2-hydroxyethoxy)-4-propyl-2H-1-benzopyran-2-one'>A1ASE</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bqc OCA], [https://pdbe.org/9bqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bqc RCSB], [https://www.ebi.ac.uk/pdbsum/9bqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bqc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alvey JA]]
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[[Category: Applova L]]
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[[Category: Arrouye L]]
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[[Category: Austin CA]]
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[[Category: Cong ATQ]]
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[[Category: Jirkovska A]]
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[[Category: Karabanovich G]]
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[[Category: Kerestes V]]
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[[Category: Kollarova P]]
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[[Category: Kubes J]]
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[[Category: Kunes J]]
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[[Category: Lencova O]]
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[[Category: Melnikova I]]
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[[Category: Paluncic J]]
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[[Category: Piskackova HB]]
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[[Category: Roh J]]
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[[Category: Schellenberg MJ]]
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[[Category: Simunek T]]
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[[Category: Sterba M]]
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[[Category: Sterbova P]]
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[[Category: Witter TL]]

Current revision

Human Topoisomerase 2 Beta ATPase domain bound to obex 5c and non-hydrolyzable ATP analog AMPPNP

PDB ID 9bqc

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OCA

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