1ss6

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{{STRUCTURE_1ss6| PDB=1ss6 | SCENE= }}
{{STRUCTURE_1ss6| PDB=1ss6 | SCENE= }}
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'''Solution structure of SEP domain from human p47'''
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===Solution structure of SEP domain from human p47===
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==Overview==
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The solution structure of the human p47 SEP domain in a construct comprising residues G1-S2-p47(171-270) was determined by NMR spectroscopy. A structure-derived hypothesis about the domains' function was formulated and pursued in binding experiments with cysteine proteases. The SEP domain was found to be a reversible competitive inhibitor of cathepsin L with a Ki of 1.5 microM. The binding of G1-S2-p47(171-270) to cathepsin L was mapped by biochemical assays and the binding interface was investigated by NMR chemical shift perturbation experiments.
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{{ABSTRACT_PUBMED_15498563}}
==About this Structure==
==About this Structure==
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1SS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS6 OCA].
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1SS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS6 OCA].
==Reference==
==Reference==
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[[Category: P47]]
[[Category: P47]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:04:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:20:06 2008''

Revision as of 03:20, 28 July 2008

Image:1ss6.png

Template:STRUCTURE 1ss6

Solution structure of SEP domain from human p47

Template:ABSTRACT PUBMED 15498563

About this Structure

1SS6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L., Soukenik M, Diehl A, Leidert M, Sievert V, Bussow K, Leitner D, Labudde D, Ball LJ, Lechner A, Nagler DK, Oschkinat H, FEBS Lett. 2004 Oct 22;576(3):358-62. PMID:15498563

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