Latrophilin

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Current revision (08:27, 26 October 2025) (edit) (undo)
 
Line 25: Line 25:
**[[2jxa]] – mLAT-1 Gal_lectin domain + rhamnose - NMR<br />
**[[2jxa]] – mLAT-1 Gal_lectin domain + rhamnose - NMR<br />
-
*Latrophilin-3
+
*Latrophilin-3; Domains – lectin 97-198; olfactomedin 199-495; GAIN and HormR 496-1160
**[[5ftt]], [[5ftu]] – hLAT-3 + FLRT2 + netrin receptor - human<br />
**[[5ftt]], [[5ftu]] – hLAT-3 + FLRT2 + netrin receptor - human<br />
-
**[[4rmk]], [[4rml]] – hLAT-3 olfactomedin domain 199-495<br />
+
**[[4rmk]], [[4rml]] – hLAT-3 olfactomedin domain <br />
-
**[[5afb]] – hLAT-3 olfactomedin and lectin domains 97-495<br />
+
**[[5afb]] – hLAT-3 olfactomedin and lectin domains <br />
**[[5cmn]] – hLAT-3 olfactomedin domain + FLRT3<br />
**[[5cmn]] – hLAT-3 olfactomedin domain + FLRT3<br />
**[[8djg]] – hLAT-3 residues 24-126 + antibody<br />
**[[8djg]] – hLAT-3 residues 24-126 + antibody<br />
Line 35: Line 35:
**[[7sf7]] – hLAT-3 residues 842-1138 + GS – Cryo EM<br />
**[[7sf7]] – hLAT-3 residues 842-1138 + GS – Cryo EM<br />
**[[7x10]] – hLAT-3 + Scfv + GS – Cryo EM<br />
**[[7x10]] – hLAT-3 + Scfv + GS – Cryo EM<br />
 +
**[[8vti]] – hLAT-3 GAIN and HormR domains 490-1160 + antibody – Cryo EM<br />
**[[4yeb]] – mLAT-3 + FLRT3 <br />
**[[4yeb]] – mLAT-3 + FLRT3 <br />
**[[6jbu]] – mLAT-3 olfactomedin domain + FLRT3<br />
**[[6jbu]] – mLAT-3 olfactomedin domain + FLRT3<br />

Current revision

Human latrophilin-3 olfactomedin domain (magenta) complex with leucine-rich repeat transmembrane protein 3 (blue) and Ca+2 ion (green) (PDB code 5cmn)

Drag the structure with the mouse to rotate

3D structures of latrophilin

Updated on 26-October-2025

References

  1. ↑ Silva JP, Ushkaryov YA. The latrophilins, "split-personality" receptors. Adv Exp Med Biol. 2010;706:59-75. PMID:21618826
  2. ↑ Matúš D, Lopez JM, Sando RC, Südhof TC. Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses. J Neurosci. 2024 Jun 5;44(23):e1978232024. PMID:38684366 doi:10.1523/JNEUROSCI.1978-23.2024
  3. ↑ Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Südhof TC. Alternative splicing of latrophilin-3 controls synapse formation. Nature. 2024 Feb;626(7997):128-135. PMID:38233523 doi:10.1038/s41586-023-06913-9
  4. ↑ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. doi: 10.1038/mp.2010.6. Epub 2010 Feb, 16. PMID:20157310 doi:http://dx.doi.org/10.1038/mp.2010.6
  5. ↑ Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Sudhof TC, Arac D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure. 2015 Jul 28. pii: S0969-2126(15)00277-4. doi:, 10.1016/j.str.2015.06.024. PMID:26235030 doi:http://dx.doi.org/10.1016/j.str.2015.06.024

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