Journal:Acta Cryst D:S2059798324005461
From Proteopedia
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==Relevance== | ==Relevance== | ||
| - | Beyond pure academic curiosity, ASNases are also studied because of their potential application as first-line drugs for the treatment of acute lymphoblastic leukemia (ALL) <ref>PMID:27440950</ref> [1-4]. By clearing L-asparagine from circulation, they starve the L-Asn-dependent malignant cells to death, while sparing the L-Asn-independent healthy cells. The first L-asparaginase introduced for clinical treatment of ALL was Elspar (EcAII from E. coli), followed by Erwinase (ErA from E. chrysanthemi). ASNases are also used in food industry to prevent the formation of acrylamide from L-Asn in fried starch foods [5, 6]. | + | Beyond pure academic curiosity, ASNases are also studied because of their potential application as first-line drugs for the treatment of acute lymphoblastic leukemia (ALL) <ref>PMID:27440950</ref><ref>PMID:31552479</ref><ref>PMID:30993718</ref> [1-4]. By clearing L-asparagine from circulation, they starve the L-Asn-dependent malignant cells to death, while sparing the L-Asn-independent healthy cells. The first L-asparaginase introduced for clinical treatment of ALL was Elspar (EcAII from E. coli), followed by Erwinase (ErA from E. chrysanthemi). ASNases are also used in food industry to prevent the formation of acrylamide from L-Asn in fried starch foods [5, 6]. |
==Dependable Structures== | ==Dependable Structures== | ||
<jmol><jmolMenu> | <jmol><jmolMenu> | ||
Revision as of 11:03, 11 July 2024
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