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1suu

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[[Image:1suu.gif|left|200px]]
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{{STRUCTURE_1suu| PDB=1suu | SCENE= }}
{{STRUCTURE_1suu| PDB=1suu | SCENE= }}
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'''Structure of DNA gyrase A C-terminal domain'''
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===Structure of DNA gyrase A C-terminal domain===
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==Overview==
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DNA gyrase is unique among enzymes for its ability to actively introduce negative supercoils into DNA. This function is mediated in part by the C-terminal domain of its A subunit (GyrA CTD). Here, we report the crystal structure of this approximately 35-kDa domain determined to 1.75-A resolution. The GyrA CTD unexpectedly adopts an unusual fold, which we term a beta-pinwheel, that is globally reminiscent of a beta-propeller but is built of blades with a previously unobserved topology. A large, conserved basic patch on the outer edge of this domain suggests a likely site for binding and bending DNA; fluorescence resonance energy transfer-based assays show that the GyrA CTD is capable of bending DNA by &gt; or =180 degrees over a 40-bp region. Surprisingly, we find that the CTD of the topoisomerase IV A subunit, which shares limited sequence homology with the GyrA CTD, also bends DNA. Together, these data provide a physical explanation for the ability of DNA gyrase to constrain a positive superhelical DNA wrap, and also suggest that the particular substrate preferences of topoisomerase IV might be dictated in part by the function of this domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 15123801 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15123801}}
==About this Structure==
==About this Structure==
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[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Topoisomerase,dna gyrase]]
[[Category: Topoisomerase,dna gyrase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:09:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:42:00 2008''

Revision as of 19:42, 27 July 2008

Image:1suu.png

Template:STRUCTURE 1suu

Structure of DNA gyrase A C-terminal domain

Template:ABSTRACT PUBMED 15123801

About this Structure

1SUU is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold., Corbett KD, Shultzaberger RK, Berger JM, Proc Natl Acad Sci U S A. 2004 May 11;101(19):7293-8. Epub 2004 May 3. PMID:15123801

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