9c7d

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Current revision (09:31, 25 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9c7d is ON HOLD until Paper Publication
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==Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein==
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<StructureSection load='9c7d' size='340' side='right'caption='[[9c7d]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors: Moskovitz, R., Wilson, I.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9c7d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C7D FirstGlance]. <br>
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Description: Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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[[Category: Wilson, I.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c7d OCA], [https://pdbe.org/9c7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c7d RCSB], [https://www.ebi.ac.uk/pdbsum/9c7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c7d ProSAT]</span></td></tr>
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[[Category: Moskovitz, R]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSP_PLAF7 CSP_PLAF7] Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).[UniProtKB:P23093]<ref>PMID:29554084</ref> <ref>PMID:32150583</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.[UniProtKB:P23093]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Moskovitz R]]
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[[Category: Wilson IA]]

Current revision

Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein

PDB ID 9c7d

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