9ilr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the GmvT-GmvA-AcCoA ternary complex== |
| + | <StructureSection load='9ilr' size='340' side='right'caption='[[9ilr]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9ilr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_sonnei Shigella sonnei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ILR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ILR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ilr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ilr OCA], [https://pdbe.org/9ilr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ilr RCSB], [https://www.ebi.ac.uk/pdbsum/9ilr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ilr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Toxin-antitoxin (TA) systems are common bicistronic gene elements in bacteria and are critical for stress responses. The toxin members of the GNAT/RHH TA family can acetylate certain aminoacylated tRNA molecules and inhibit global protein translation. One member named GmvT is important for virulence plasmid maintenance in Shigella flexneri, but the underlying mechanism remains poorly understood. Here, we report the cocrystal structures of GmvT in two forms. The binding of the antitoxin mainly relies on the backbone of the toxin while the cofactor is free of contacts with the antitoxin, supported by follow-up in vitro and in vivo studies. Our study provides insight into the protein-protein/protein-ligand interactions of the GmvAT pair and the structural basis for molecular recognition. | ||
| - | + | Structural insights into the Shigella flexneri GmvAT toxin-antitoxin system.,Chen R, Zhao H, Zhou J, Liu A, Guo Y, Wu K, Xiang Y, Lei J, Jiang S, Xie W FEBS Lett. 2025 Feb 20. doi: 10.1002/1873-3468.70015. PMID:39973444<ref>PMID:39973444</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 9ilr" style="background-color:#fffaf0;"></div> |
| - | [[Category: Xie | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Shigella sonnei]] | ||
| + | [[Category: Chen R]] | ||
| + | [[Category: Xie W]] | ||
| + | [[Category: Zhao H]] | ||
Current revision
The structure of the GmvT-GmvA-AcCoA ternary complex
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