1svz

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[[Image:1svz.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1svz| PDB=1svz | SCENE= }}
{{STRUCTURE_1svz| PDB=1svz | SCENE= }}
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'''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''
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===Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease===
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==Overview==
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The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15721587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15721587}}
==About this Structure==
==About this Structure==
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[[Category: Antibody-antigen complex]]
[[Category: Antibody-antigen complex]]
[[Category: Hiv inhibiting antibody]]
[[Category: Hiv inhibiting antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:12:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:50:21 2008''

Revision as of 17:50, 28 July 2008

Image:1svz.png

Template:STRUCTURE 1svz

Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease

Template:ABSTRACT PUBMED 15721587

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587

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