9coo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Nanobody 4 bound to Apolipoprotein B 100== |
| - | + | <StructureSection load='9coo' size='340' side='right'caption='[[9coo]], [[Resolution|resolution]] 3.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9coo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_bactrianus Camelus bactrianus], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9COO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.73Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9coo OCA], [https://pdbe.org/9coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9coo RCSB], [https://www.ebi.ac.uk/pdbsum/9coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9coo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Homozygous familial hypercholesterolemia. The disease is caused by variants affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844).<ref>PMID:21981844</ref> The disease is caused by variants affecting the gene represented in this entry. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Camelus bactrianus]] | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dearborn AD]] | ||
| + | [[Category: Graziano G]] | ||
| + | [[Category: Kumar A]] | ||
| + | [[Category: Lei H]] | ||
| + | [[Category: Marcotrigiano J]] | ||
| + | [[Category: Neufeld EB]] | ||
| + | [[Category: Reimund M]] | ||
| + | [[Category: Remaley AT]] | ||
Current revision
Nanobody 4 bound to Apolipoprotein B 100
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