From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | [[Image:1sxr.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1sxr.png|left|200px]] |
| | | | |
| | <!-- | | <!-- |
| Line 9: |
Line 10: |
| | {{STRUCTURE_1sxr| PDB=1sxr | SCENE= }} | | {{STRUCTURE_1sxr| PDB=1sxr | SCENE= }} |
| | | | |
| - | '''Drosophila Peptidoglycan Recognition Protein (PGRP)-SA'''
| + | ===Drosophila Peptidoglycan Recognition Protein (PGRP)-SA=== |
| | | | |
| | | | |
| - | ==Overview==
| + | <!-- |
| - | Peptidoglycan recognition proteins (PGRPs) form a recently discovered protein family, which is conserved from insect to mammals and is implicated in the innate immune system by interacting with/or degrading microbial peptidoglycans (PGNs). Drosophila PGRP-SA is a member of this family of pattern recognition receptors and is involved in insect Toll activation. We report here the crystal structure of PGRP-SA at 1.56 A resolution, which represents the first example of a "recognition" PGRP. Comparison with the catalytic Drosophila PGRP-LB reveals an overall structure conservation with an L-shaped hydrophilic groove that is likely the PGN carbohydrate core binding site, but further suggests some possible functional homology between recognition and catalytic PGRPs. Consistent with sequence analysis, PGRP-SA does not contain the canonical zinc-binding residues found in catalytic PGRPs. However, substitution of the zinc-binding cysteine residue by serine, along with an altered coordinating histidine residue, assembles a constellation of residues that resembles a modified catalytic triad. The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_15223330}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 15223330 is the PubMed ID number. |
| | + | --> |
| | + | {{ABSTRACT_PUBMED_15223330}} |
| | | | |
| | ==About this Structure== | | ==About this Structure== |
| Line 29: |
Line 33: |
| | [[Category: Peptidoglycan]] | | [[Category: Peptidoglycan]] |
| | [[Category: Toll pathway]] | | [[Category: Toll pathway]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:15:33 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:57:41 2008'' |
Revision as of 20:57, 28 July 2008
Template:STRUCTURE 1sxr
Drosophila Peptidoglycan Recognition Protein (PGRP)-SA
Template:ABSTRACT PUBMED 15223330
About this Structure
1SXR is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:15223330
Page seeded by OCA on Mon Jul 28 23:57:41 2008
