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1sxr

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{{STRUCTURE_1sxr| PDB=1sxr | SCENE= }}
{{STRUCTURE_1sxr| PDB=1sxr | SCENE= }}
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'''Drosophila Peptidoglycan Recognition Protein (PGRP)-SA'''
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===Drosophila Peptidoglycan Recognition Protein (PGRP)-SA===
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==Overview==
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Peptidoglycan recognition proteins (PGRPs) form a recently discovered protein family, which is conserved from insect to mammals and is implicated in the innate immune system by interacting with/or degrading microbial peptidoglycans (PGNs). Drosophila PGRP-SA is a member of this family of pattern recognition receptors and is involved in insect Toll activation. We report here the crystal structure of PGRP-SA at 1.56 A resolution, which represents the first example of a "recognition" PGRP. Comparison with the catalytic Drosophila PGRP-LB reveals an overall structure conservation with an L-shaped hydrophilic groove that is likely the PGN carbohydrate core binding site, but further suggests some possible functional homology between recognition and catalytic PGRPs. Consistent with sequence analysis, PGRP-SA does not contain the canonical zinc-binding residues found in catalytic PGRPs. However, substitution of the zinc-binding cysteine residue by serine, along with an altered coordinating histidine residue, assembles a constellation of residues that resembles a modified catalytic triad. The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15223330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15223330}}
==About this Structure==
==About this Structure==
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[[Category: Peptidoglycan]]
[[Category: Peptidoglycan]]
[[Category: Toll pathway]]
[[Category: Toll pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:15:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:57:41 2008''

Revision as of 20:57, 28 July 2008

Image:1sxr.png

Template:STRUCTURE 1sxr

Drosophila Peptidoglycan Recognition Protein (PGRP)-SA

Template:ABSTRACT PUBMED 15223330

About this Structure

1SXR is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:15223330

Page seeded by OCA on Mon Jul 28 23:57:41 2008

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