1sys

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sys.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sys.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sys| PDB=1sys | SCENE= }}
{{STRUCTURE_1sys| PDB=1sys | SCENE= }}
-
'''Crystal structure of HLA, B*4403, and peptide EEPTVIKKY'''
+
===Crystal structure of HLA, B*4403, and peptide EEPTVIKKY===
-
==Overview==
+
<!--
-
HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation. This mode of peptide capture is less susceptible to viral interference than the conventional loading pathway used by HLA-B*4402 that involves assembly of class I molecules within the peptide loading complex. Thus, B*4402 and B*4405 are at opposite extremes of a natural spectrum in HLA class I dependence on the PLC for Ag presentation. These findings unveil a new layer of MHC polymorphism that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15226359}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15226359 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15226359}}
==Disease==
==Disease==
Line 45: Line 49:
[[Category: Hla]]
[[Category: Hla]]
[[Category: Mhc]]
[[Category: Mhc]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:56:40 2008''

Revision as of 06:56, 28 July 2008

Image:1sys.png

Template:STRUCTURE 1sys

Contents

Crystal structure of HLA, B*4403, and peptide EEPTVIKKY

Template:ABSTRACT PUBMED 15226359

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1SYS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion., Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J, J Exp Med. 2004 Jul 5;200(1):13-24. Epub 2004 Jun 28. PMID:15226359

Page seeded by OCA on Mon Jul 28 09:56:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sys"
Personal tools